منابع مشابه
Recent Advances in Hemophilia Gene Therapy
Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...
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The median life expectancy for cystic fibrosis is now over 30 years, and it is projected that in newborn infants it will become more than 40 years. The identification of the cystic fibrosis gene and its product, cystic fibrosis transmembrane conductance regulator (CFTR), has widened the spectrum of the disease from the classical case of the infant with cystic fibrosis to the elderly childless m...
متن کاملRECENT ADVANCES Hepatitis C-Z: recent advances
HEPATITIS C Hepatitis C (HCV) is a flavivirus which was cloned in 1989, when it was identified as the major cause of post-transfusion hepatitis in adults and children. It is an RNA virus with a high degree of heterogeneity, which results in the rapid accumulation of mutations so that many variants may coexist in a single patient. This genetic diversity allows the virus to avoid immune surveilla...
متن کاملCytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus: From Basics to Recent Advances
Systemic lupus erythematosus (SLE) is a complex auto-immune disorder which involves various facets of the immune system. In addition to autoantibody production and immune complex deposition, emerging evidences suggest that cytokines may act as key players in the immunopathogenesis of SLE. These cytokines assume a critical role in the differentiation, maturation and activation of cells and also ...
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ژورنال
عنوان ژورنال: Physical Sciences Reviews
سال: 2017
ISSN: 2365-659X
DOI: 10.1515/psr-2017-5001